The Role of Gamma Glutamyltransferase in Adaptatiogenesis and Human Organism General Resistance Realized by Connective Tissue Participating in Neuromediatory Balance and Structure-Regulation Functions (Part I)

Chernobrovkina T.V., Kershengolts B.M.

Possible role of gamma-glutamyltransferase (GGT) in individual sensibility to alcohol and alcohol-induced pathology such, mechanisms of organism resistances regulation including allergic sensitiveness  and some forms of collagen's diseases development are discussed.  This supposition is based on the next reasons: 1. The detoxification role of GGT may be conditioned by the participating in glutathione metabolism. 2. GGT can regulate  the cells and tissues amino acids pools by facilitation their transport through the  cell membranes as known the GGT- regulating function in blood-brain barriers permeability. 3. The enzyme GGT-system participates in collagen polypeptides complex synthesis and catabolism processes and this way is able to regulate the collagen metabolic state and diseases of connective tissue. 4. GGT may be included into mechanisms of some physiological effects of histamine by means of chemical binding and deactivation of high histamine concentration with the gamma-glutamylhistamine producing. It is a molecular base of antiallergic efficiency of GGT. 5. Besides GGT possibly  participates in concentration level and function balances of neuromediators (adrenaline, noradrenalin, serotonin, dopamine, histamine) which are substrates of sympathetic and parasympathetic nervous systems. 6. It was found that the   GGT level is differ in T- and B-subclasses of lymphocytes during some infection and other diseases. So in normal physiological GGT may be trigger enzyme system for the resistance and immune competence optimal state.   Abnormal  blood and tissues GGT (very high or low activity) may be effective marker in diagnostic and prognostic problems, for example collagen diseases connected with deregulations (destruction, dysplasia) of connective tissues. Perspectives porpoise steps and new mechanisms of some drugs and non-medicamentous  factors in regulation of the GGT state may be useful for enzyme therapy in pathological processes as such as in rehabilitation.

Key words: gamma-glutamyltransferase, adaptation reactivity, systemic resistances, gamma-gluta-mylhistamine, connective tissue diseases, enzyme diagnostic, enzyme therapy. 

Science and Education, 2015, No.1, pp.100-109