Molecular Mechanisms of Regulation of Insulin Secretion from β-cells of Langergans'sIslets and Promising Targets for Pharmacological Intervention of Diabetes Mellitus

Sharoyko V.V., Tennikova T.B.


The information about molecular mechanisms underlying insulin secretion in β-cells of islets of Langerhans is of paramount importance in understanding of molecular pathogenesis of diabetes mellitus and is fundamental basis for the development of modern pharmaceutical pathogenetic therapy for diabetes mellitus and its complications. The review presents the current data for the study of molecular and biological aspects of the regulation of insulin secretion. The promising targets for pharmacological intervention of diabetes mellitus are discussed.


Key words:β-cells, islets of Langerhans, insulin secretion, diabetes, pathogenetic therapy.

Science and Education, 2015, No.2, pp.91-98